Flavin-containing monooxygenases (FMOs)
Flavin-containing monooxygenases are known for their broad substrate specificity and their ability to perform oxygenations of e.g. amines and sulfides. Some bacterial FMOs were shown to perform hydroxylation of indoles (MeFMO) while the human FMO5 was recently shown to be able to perform various Baeyer-Villiger oxidations. Below some of the GECCO FMOs are highlighted, while we also can offer other microbial FMOs.
- MeFMO – Methylophaga aminisulfidivorans flavin-containing monooxygenase, available in two formats: (1) recombinant MeFMO and (2) recombinant MeFMO fused to a cofactor recycling dehydrogenase (Org Biomol Chem. 2011 Mar 7;9(5):1337-41. doi: 10.1039/c0ob00988a)
- Rhodococcus jostii RHA1 flavin-containing monooxygenases: eight different FMOs belonging to class B monooxygenases (J Mol Cat B Enz 88, 2013, 20–25)
- Human FMO5 (ACS Chem Biol. 2016, 11(4):1039-48)